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MUR1
The MUR1 encodes the Arabidopsis enzyme, GDP-d-mannose-4,6-dehydratase, which catalyzes
the first step in the de novo synthesis of GDP-l-fucose from GDP-mannose. All polysaccharides
and glycoproteins of the shoot are fucose null. The fucosyl transferases
may sometimes replace a portion of the fucosyl residues with l-galactose.
References:
Reiter, W-D., C. C. S. Chapple,
C. R. Somerville. 1993. Altered growth and cell walls in a fucose-deficient
mutant of Arabidopsis. Science 261, 1032-1035.
Bonin, C. P., I. Potter, G. F. Vanzin, W-D. Reiter. 1997. The
MUR1 gene of Arabidopsis thaliana encodes an isoform of GDP-d-mannose-4,6-dehydratase, catalyzing the
first step in the de novo synthesis of GDP-l-fucose. Proc. Natl. Acad. Sci. USA
94, 2085-2090.
Bonin,
C. P., W-D. Reiter. 2000. A bifunctional epimerase-reductase acts
downstream of the MUR1 gene product and completes the de
novo synthesis of GDP-l-fucose in Arabidopsis. Plant J.
21, 445-454.
Bonin,
C. P., G. Freshour, M. G. Hahn, G. F. Vanzin, W-D Reiter. 2003.
The GMD1 and GMD2 genes of Arabidopsis encode isoforms
of GDP-d-Mannose 4,6-Dehydratase with cell type-specific
expression patterns. Plant Physiol.
132, 883-892.
Freshour, G., C. P. Bonin, W-D Reiter, P. Albersheim, A. G.
Darvill, M. G. HahnA. 2003. Bifunctional
epimerase-reductase acts downstream of the MUR1 gene product
and completes the de novo synthesis of GDP-l-fucose
in Arabidopsis. Plant Physiol. 131, 1602-1612.
Christopher P. Bonin, Glenn Freshour, Michael G. Hahn, Gary F. Vanzin, and Wolf-Dieter Reiter. 2003. The GMD1 and GMD2 Genes of Arabidopsis Encode Isoforms of GDP-D-Mannose 4,6-Dehydratase with Cell Type-Specific Expression Patterns. Plant Physiol 132, 883-892.
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